NFL WEEK 16 - SF 49ERS vs AZ CARDINALS

In 58 meetings between these teams over the years, San Francisco has a 31-27 record. The 49ers have won 2 of the last 3 games, with the Cardinals winning 24-20 most recently in Week 1 of this season. 

This Saturday at 4:30, the Arizona Cardinals host the San Francisco 49ers. The game will be played at State Farm Stadium.

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49ers vs cardinals

SAN FRANCISCO 49ERS @ ARIZONA CARDINALS

The Cardinals ended a 3 game losing streak in Week 14 with back-to-back wins, defeating the Giants 26-7 and the Eagles 33-26. Arizona has now won 3 of their past 6 games.

San Francisco hasn't played well recently; the team has lost 5 of their last 6 games. The 49ers enter Week 16 riding a 3 game losing streak, including losses to Buffalo, Washington, and Dallas.

SAN FRANCISCO 49ERS +210 | 3.10

The 5-9 49ers have been eliminated from the playoffs just 1 year after reaching the Super Bowl last season. San Francisco is looking at an early first-round pick in the 2021 NFL Draft.

With Jimmy Garoppolo and Nick Mullens both sidelined, QB C.J. Beathard will get the start vs. the Cardinals. In 4 games, Beathard has completed 62.2% of his passes for 332 yards, 2 TDs, and 0 interceptions. San Francisco's defense had a solid year, averaging 314.3 yards and 25.1 points per game.

RB Jeff Wilson Jr.
The 3rd year RB has had a solid year for San Francisco. In 10 games, Wilson has rushed for 341 yards and 6 TDs, averaging 4.1 yards per carry. He also has 9 receptions for 100 yards and 1 TD.

WR Brandon Aiyuk
The 2020 1st rounder out of Arizona State has had an amazing rookie year for the 49ers. Aiyuk leads the team with 59 receptions for 733 yards and 5 TDs. Aiyuk has rushed for 61 yards and 2 TDs as well.

Injured Reserve
QB: Jimmy Garoppolo, Nick Mullens
RB: JaMycal Hasty, Raheem Mostert
WR: Jalen Hurd, Chris Thompson, Deebo Samuel
TE: George Kittle
OL: Tom Compton, Ben Garland
DL: Nick Bosa, Dee Ford, Solomon Thomas
DE: Ezekiel Ansah
CB: Jamar Taylor, Ken Webster
S: Jaquiski Tartt
COVID-19 Reserve
RB: Austin Walter
WR: Trent Taylor
TE: Charlie Woerner
OL: Colton McKivitz

WR Richie James, OL Hroniss Grasu, DT Javon Kinlaw, DL Dion Jordan, CB Richard Sherman, CB Jason Verrett, DB Jimmie Ward, and DB Tarvarius Moore are all questionable for Week 16.

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ARIZONA CARDINALS -250 | 1.40 

The 8-6 Cardinals are hoping to make their first postseason appearance since 2015. Arizona needs a win and a Chicago loss/tie OR an ARZ tie and a Bears loss to clinch a spot in the playoffs this week.

QB Kyler Murray was elected to his first Pro Bowl this season. Murray has completed 67.6% of his passes for 3,637 yards, 26 TDs, and 11 interceptions. The former Offensive Rookie of the Year has rushed for 741 yards and 11 TDs as well. Arizona's defense has had a strong year, averaging 350 yards and 23.5 points per game.

RB Kenyan Drake
The 2016 3rd rounder has been great in his second year with the Cardinals. Drake has 9 TDs on the season and ranks 9th in the NFL with 874 rushing yards. Drake also has 20 receptions for 117 yards.

WR DeAndre Hopkins
The 5x Pro Bowler has been outstanding in his first year with Arizona. Hopkins has 6 TDs, 103 receptions, and leads the NFL with 1,324 yards. Hopkins also has 476 yards after the catch and 71 first downs.

Injured Reserve
DT: Corey Peters
DE: Jordan Phillips
LB: Isaiah Irving, Chandler Jones
CB: Johnathan Joseph, Robert Alford
K: Zane Gonzalez

RB Chase Edmunds (ankle/knee), WR Larry Fitzgerald (groin), TE Maxx Williams, TE Darrell Daniels, OL Mason Cole, OL Justin Pugh, DT Domata Peko Sr., OLB Kylie Fitts, OLB Haason Reddick, OLB Dennis Gardeck, CB Dre Kirkpatrick, and S Jalen Thompson are all questionable for Week 16.

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